Zur toxikologie der losungsmittel (verschiedene ester, aceton, methylalkohol). The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website.  |  2008;27 Suppl 2:25-39. doi: 10.1080/10915810802244439. Raw materials data handbook, physical and chemical properties, fire hazard and health hazard data. Extremely flammable liquid and vapor! When released into the air , this material may be moderately degraded by reaction with photochemically produced hydroxyl radi cals. NLM ��*0)a���uŠB��KuS����xbS���/��ęx�ek��e�g�~ٓ�X�[W�"�Ek��I�lAܞ'����X�%��Ɋ���ʶc���ݟw�_v�J�Gڐ���ruN�d9�^ԳO�#-��DV?��œ��ԭC�l%��K�^��dۭ4��Z.�b�~΁�e+��f���^!.Y���-����m0�~�?ك�]J���:$�x���i$�hdܚFb#�yk���)�2/��`Z^q��YA8CMi쵠.�0iZ�u ��F#4Z1@M�m;��Z)��4��X-�ت� �#���^���s�kX�=���(��E�$�� �1��yʤ�L�v��H�Q��,tڴ��"U�jDP}RRF3�ڂ;��A9 Page 6 of 7 MSDS ± Butyl Acetate expected to have a half-life between 1 and 10 days. 2006 Dec;46(3):243. 1943]. Basis for revised IDLH: Based on health considerations and acute inhalation toxicity data in humans [Grant 1974], a value of about 3,300 ppm would have been appropriate for n-butyl acetate. Improved communication: hygienic standards for daily inhalation. An inhalation unit risk value for TBAc of 4 x 10(-7)(microg/m(3))(-1) can then be derived from the CSF value for TBAc by assuming a human breathing rate of 20 m3/day, 70% fractional absorption, and an average human body weight of 70 kg. HAZARDS IDENTIFICATION Danger! NIH Ethyl tertiary-butyl ether: a toxicological review. Final report on the safety assessment of methoxyisopropanol and methoxyisopropyl acetate as used in cosmetics. Yang YS, Lee J, Kwon S, Seo HS, Choi SJ, Yu HJ, Song JA, Lee K, Lee BS, Heo JD, Cho KH, Song CW. Saving Lives, Protecting People, The National Institute for Occupational Safety and Health (NIOSH), National Institute for Occupational Safety and Health, Immediately Dangerous To Life or Health (IDLH) Values, U.S. Department of Health & Human Services. 2. UCC [1987]. [From ACGIH [1991]. Int J Toxicol. Vol. An acute 1-h reference exposure level of 1 mg/m3 can be calculated from the extrapolated no observed adverse effect level of 50 mg/m3. 2nd ed. Human data: Severe irritation of the throat has been reported in volunteers exposed to 300 ppm for 3 to 5 minutes [Nelson et al. uuid:b56296fb-05fb-1f46-ab63-d33e8b4fe017 Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Limited chronic toxicity data exist for TBAc. 50-135, November 17, 1987. ACGIH [1971]. NIOSH REL: 150 ppm (710 mg/m3) TWA, 200 ppm (950 mg/m3) STEL, Current OSHA PEL: 150 ppm (710 mg/m3) TWA, 1989 OSHA PEL: 150 ppm (710 mg/m3) TWA, 200 ppm (950 mg/m3) STEL, 1993-1994 ACGIH TLV: 150 ppm (713 mg/m3) TWA, 200 ppm (950 mg/m3) STEL. Nelson KW, Ege JF, Ross M, Woodman LE, Silverman L [1943]. �C�VE�������H��d�v����єĄf�2F蜰$!y��X����Ou5�G��wcz��� CDC twenty four seven. CDC is not responsible for Section 508 compliance (accessibility) on other federal or private website. Other animal data: A 4-hour exposure to 10,000 ppm was not lethal to rats [Smyth 1956]. H���n�H���,�hd�Eޠ_@��A��"���*��w3�4�,���F�^�f�G��s���d�VҒ;��h�T?��w� �tt������T�7q�e��*��a���.M�����c���I'��~�?���"�H��ҿ��$'kg㯵a�w/^K��Sty8:�uqD"�����K8*��V���!��6�yW*��V��I�LW|�v��D��R��S�5QRE�߅FCi��A6Uqh�뺊D"�N����p�x�� �q">Zj��$x7�u�E"�h��� hC$�Y�ָ�y[���bz��>��a\��}])]�l��T�mw�8D"�h�j)�Fiw="��˓��E+-���,���I���wU?�K^�$�����E"�c�����ʹ��Ż6aR09���`)-��g� 3 / 17 BUTYL ACETATE Safety Data Sheet BUTYL ACETATE Version 1.0 Date: 06/01/2015 Hazardous components CAS-No. Description of Substance: Colorless liquid with a fruity odor. 6. Epub 2015 Jan 28.  |  FIRST AID MEASURES General advice : Move out of dangerous area. Sensory response to certain industrial solvent vapors. TBA has been shown to induce tumors in both rats and mice, and the Office of Environmental Health Hazard Assessment has calculated an oral cancer potency factor (CSF) for TBA of 3 x 10(-3)(mg/kg-day)(-1). However, the revised IDLH for n-butyl acetate is 1,700 ppm based strictly on safety considerations (i.e., being 10% of the lower explosive limit of 1.7%). Food Cosmet Toxicol [1979]; 17:515-519. m�Z Harmful if swallowed. 3rd ed. Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Arch Gewerbepath Gewerbehyg 5:1-90 (in German). 3. 5. Show this safety data sheet to the doctor in attend- ance. }��D��O�ʠfœ���!��!�Z��(� `�l�s���8� �oEq����9�e�%}z�o�_5_����� Smyth HF Jr [1956]. Crit Rev Toxicol. NORMAL BUTYL ACETATE 1. 2015 Feb;45(2):142-71. doi: 10.3109/10408444.2014.980884. Additionally, TBAc has been demonstrated to be substantially metabolized to tert-butanol (TBA) in rats, and a positive TBA genotoxicity study suggests that TBA may cause oxidative DNA damage. 164-165.]. BUTYL ACETATE is an ester. 210-211. ,�իsN�5H�. Basis for original (SCP) IDLH: The chosen IDLH is based on the statement by ACGIH [1971] that a 4-hour exposure to 10,000 ppm killed no rats, but an 8-hour exposure to 10,000 ppm killed all 6 rats [Smyth 1956]. ��} m�_���5*v����7����Zi��xpLQ?�D�G"d�PO8�WL��x� �F�J�F�/x�ʽ����i�F&�kp�+�ན���yf"��E�PWRҺ��O�*�!�! However, it has also been reported that irritation of the eyes and nose is first objectionable at 3,300 ppm and that higher concentrations cause tearing and hyperemia of the conjunctiva [Grant 1974]. Adobe PDF Library 10.1 Am Ind Hyg Assoc Q 17(2):129-185. 4. Flury F, Wirth W [1933]. %PDF-1.6 %���� h�ܑ�j�@�_�>A�;?�BpѴ�PJ%fQ�%�h� ط�q"]t�mE=s�{Ν�Q�!�(&Ŗ,�P�)�21n�B����Fl�k�Ɋ��i�p�j�&AӠp���ǯO'��ݍY�:�:?�~��N�澟��><1K�M�5|�I�փ��к1��ߕ����dRa6JI:��2�c>� ;9xnSsIl��b����J�8�ɋ��������õs��¤��"�,�!�.�ſ�%"����W�B��CR�C��C��!�:N�[� N�� endstream endobj 54 0 obj <>stream Immunotoxicity and allergic potential induced by topical application of dimethyl carbonate (DMC) in a murine model. Harmful if inhaled. McGregor DB, Cruzan G, Callander RD, May K, Banton M. Mutat Res. Salsmon, Andrew G [corrected to Salmon, Andrew G], Regul Toxicol Pharmacol. n-Butyl acetate: acute vapor inhalation toxicity test in rats. Esters react with acids to liberate heat along with alcohols and acids. HHS Birth Defects Res B Dev Reprod Toxicol. Human health screening level risk assessments of tertiary-butyl acetate (TBAC): calculated acute and chronic reference concentration (RfC) and Hazard Quotient (HQ) values based on toxicity and exposure scenario evaluations. 2016-02-26T11:36:02-05:00 Therefore, TBAc should be considered to pose a potential cancer risk to humans because of the metabolic conversion to TBA. 1. Linking to a non-federal website does not constitute an endorsement by CDC or any of its employees of the sponsors or the information and products presented on the website. �BΒ���ֺ3R�l%j��m�}]��D�����Q+B�P o#E�Kwo�8�N�X�7��!G&]L6����0 A"x� endstream endobj 1 0 obj <> endobj 2 0 obj <>stream Get the latest public health information from CDC: https://www.coronavirus.gov. Causes skin and eye irritation. However, the revised IDLH for n-butyl acetate is 1,700 ppm based strictly on safety considerations (i.e., being 10% of the lower explosive limit of 1.7%). TSCA section 8e submission and status report on n-butyl acetate. Cincinnati, OH: American Conference of Governmental Industrial Hygienists, pp. 7. 8EHQ-0387-0659, April 6, 1987. tert-Butyl acetate (TBAc) is an industrial chemical with potential uses as a degreaser and in architectural coatings. This site needs JavaScript to work properly. Vapor concentrations may cause drowsiness. However, acute inhalation exposure data are available for TBAc. Clipboard, Search History, and several other advanced features are temporarily unavailable. 2007. NPIRI [1974]. In: Documentation of the threshold limit values for substances in workroom air. Yakkyoku (Pharmacy) [1981]; 32(10):1241-1247 (in Japanese). Regul Toxicol Pharmacol. 2016-02-26T11:36:03-05:00 9. The mutagenicity testing of tertiary-butyl alcohol, tertiary-butyl acetate and methyl tertiary-butyl ether in Salmonella typhimurium. You will be subject to the destination website's privacy policy when you follow the link. �0�W�.�6)� LC50 Determination of tert-Butyl Acetate using a Nose Only Inhalation Exposure in Rats. In: Documentation of the threshold limit values and biological exposure indices. Get the latest research from NIH: https://www.nih.gov/coronavirus. Thomas, pp. Toxicol Res. 1. Yang YS, Ahn TH, Lee JC, Moon CJ, Kim SH, Park SC, Chung YH, Kim HY, Kim JC. 10. endstream endobj 4 0 obj <> endobj 12 0 obj <>stream COVID-19 is an emerging, rapidly evolving situation. Springfield, IL: C.C. Washington, DC: U.S. Environmental Protection Agency, Office of Toxic Substances, Report No. [From ACGIH [1991].

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